Orbital metastasis from prostate cancer.

To cite: Ahmed M, Begum T. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015211447 DESCRIPTION An 82-year-old man presented with proptosis, progressive throbbing pain and blurry vision in the right eye, gradually worsening over the past 3 weeks. The patient was diagnosed with prostate cancer and had undergone a radical prostatectomy nearly 14 years prior. After the surgery, his prostate-specific antigen (PSA) levels remained normal on regular follow-up, although he did not visit an oncologist for the past 4 years. He did not report bony pain, weight loss or headache. His thyroid function was normal. CT of the orbit showed a soft tissue mass within the right orbit, with bony destruction of the greater wing of sphenoid, and optic nerve compression (figures 1 and 2, yellow arrow). CT of the abdomen and pelvis showed osteosclerotic lesions involving multiple vertebral bodies and the right iliac bone. His PSA level was 4.4 ng/mL. A biopsy from the iliac bone confirmed prostatic adenocarcinoma. The patient was started on androgen suppression with leuprolide and methylprednisolone, and radiotherapy was initiated. His symptoms improved initially, but he started to develop more lesions in the right frontal lobe. Considering his age and the aggressive nature of the disease, the patient decided to opt for hospice care. He died a couple of months later. Metastasis to the orbit from a solid tumour is rare. Among the different malignancies, breast cancer most commonly metastasises to the orbit. Prostate cancer was found to be the second or third most common source in different case series. The orbit is the second most common area of unusual metastasis from prostate cancer, atypical lymph node metastasis being the first (figure 3). In that report, the mean age of the patients was 70.5 years (range 60–90 years). The left and right orbits were both involved at a similar frequency, with bilateral involvement in some cases. The mean time period between the prostate cancer diagnosis and the orbital metastasis was 3.7 years (range 1–8 years). On a few occasions, orbital metastasis was the presenting symptom of prostate cancer. PSA levels may be within normal range at the time of first manifestation of metastatic disease. CT scan is the imaging study of choice, and MRI is also very sensitive. Radiotherapy and steroids were used simultaneously as palliative therapy. Except for one case, all the patients expired within 1 year of metastasis.